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Although electronic cigarettes or e-cigarettes have been marketed as a safer alternative to cigarettes, Spiegel says those claims are largely lacking in scientific data

[12] Anxiety: Generalized anxiety disorder (GAD) is characterized by persistent and excessive worry, often accompanied by physical symptoms such as chest pain, restlessness, fatigue, and muscle tension [33] Clinical depression: Depression, linked to chest pain through its physical and emotional effects, has been shown in studies to independently increase the long-term risk of coronary heart disease (CHD) and myocardial infarction (MI), potentially contributing to cardiovascular disease

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However, many naturally occurring psychoactive plants and animals are facing threats from climate change, habitat loss and other anthropogenic pressures like overharvesting