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The effects of oestrogens and their receptors on cardiometabolic health

Examples include the microbial metabolism of bile acids 73,74 , which function in nutrient absorption and as endogenous agonists of farnesoid-X receptor (FXR) 75,76 , as well as propionate and butyrate 77 , simple short-chain fatty acids that play key roles in the maintenance of intestinal immune homeostasis 78

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In the general population, tramadol also carries risks for hypoglycemia, hyponatremia, and serotonin syndrome, and a recent systematic review found only modest pain relief with increased serious adverse events [18,19,20].These risks are particularly concerning in patients with cirrhosis, who are already predisposed to metabolic derangements