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[PubMed] [Google Scholar] 43.Murata J, Ricciardi-Castagnoli P, Mange PD, Martin F, Juillerat-Jeanneret L

Metformin, a diabetes drug, alters the gut microbiome and increases SCFAs and bile acids that activate GLP-1, which has led to exploration of metformin in AD and PD trials for its possible MGBA benefits [278, 279]

TRPM2 is a non-selective cation channel with Ca 2+ permeability

Therefore, while these preclinical findings are valuable for understanding LDHA as a target, their therapeutic readiness should not be overstated, and further research is crucial to assess their true clinical potential