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fragilis binds to TLR-2 and promotes the differentiation of CD4 + lymphocytes to Treg lymphocytes, along with the production of anti-inflammatory cytokines such as IL-10 ( Segmented Filamentous Bacteria , as a commensal bacterium, influence the adaptive and innate immune systems by increasing IgA secretion and the development of Th17 lymphocytes ( The skin, being the bodys largest organ, serves as a physical barrier against environmental damage and as a dynamical interface for host-skin-microbe interactions

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The mobile phase consisted of (A) 0.1% formic acid in water and (B) 0.1% formic acid in acetonitrile