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Additionally, the upregulation of ribosomal proteins enhances protein synthesis, and glycolytic enzyme overexpression boosts energy production, collectively contributing to the parasites survival and resistance ( A comparative overview of resistance mechanisms across major antileishmanial drugs is provided in Table 3, highlighting recurrent themes such as transporter upregulation, metabolic adaptations, and genetic mutations

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All these perturbations are implicated in mitochondrial dysfunction, hence strategies to mitigate this may pose an important therapeutic avenue

Total isothiocyanate yield from raw cruciferous vegetables commonly consumed in the United States