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The risks associated with variants in PMS2 are much lower than the risks associated with variants in MLH1

doi: 10.3389/fphar.2022.902102 224 LiPWangYYanQYangYZhuRMaJet al

Ultimately, it will result in death ( Under normal physiological conditions, ROS/RNS result from metabolic processes

At the tumor site, PMIR effectively inhibits glutamine metabolism in tumor cells, leading to an elevation in intratumoral glutamine levels and improving immune cell functionality, ultimately reshaping the immunosuppressive TME and evoking robust immune responses [204]