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Deymeer et al., Pathophysiology of MuSK-MG The AChR Clustering Pathway To understand how autoantibodies directed against MuSK impair transmission at the NMJ, leading to the full clinical spectrum of myasthenia, it is necessary to understand the key function of MuSK in the development and maintenance of the NMJ and particularly in the clustering of AChRs (Figure 1)

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