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2.1 Protein metabolism in plant roots and shoots due to drought stress Prolonged water deficit in the soil causes drought, which vastly affects the metabolism and physiological function in growing plant especially roots and responsive for water supply from soils to leaves and photosynthesis, respectively

Currently, the approved HDACi in clinical practice has limited application possibly due to the pan-HDAC inhibition profile

SD-436 has no significant inhibition of the human ether-a-go-go-related gene potassium channels (hERG inhibition: 1.3% for 3M and 1.1% for 30 M) [1]

Ideal alternatives would incorporate mechanisms of action that lower the risk of resistance