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The BMAL1:CLOCK heterodimer promotes Smad3 expression, suggesting that circadian genes may regulate BMSCs' osteogenic differentiation through modulation of the Smad family

However, these feedback mechanisms are often epigenetically hijacked [126]

These tubules are responsible for reabsorbing nutrients and filtering out waste

Chem Res Toxicol 25(8):16161632 Tirmenstein MA, Nelson SD (1989) Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3-hydroxyacetanilide, in mouse liver