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Pro-inflammatory stimuli induce the activation of specific pathways through the stabilization of transcription factors such as nuclear factor (NF)-B and hypoxia-inducible factor (HIF)-1, which trigger the expression of markers like inducible nitric oxide synthase (iNOS), CD80, and CD86 and the release of tumor necrosis factor (TNF)-, IL-1, IL-6, IL-12, and IL-23

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American Academy of Dermatology meeting, February 2002

Chiropractic care is often integrated with physical therapy, exercise, and rehabilitation