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10.1093/cvr/cvw249 131 SharmaJ

But physicians aim to help manage the unpleasant symptoms

Hypermethylation of multiple genes can occur simultaneously in a tumor, such as APC, DKPK1, MGMT, P16, and RASSF1 in lung cancer, while others, like RASSF1 and P16, could be hypermethylated in a variety of tumors (Castro et al., 2010)