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in Table 2), and pharmacological, behavioral, and peripheral interventions that also affect the brain such as neurotransmitter modulators (e.g., duloxetine, bupropion), peripheral nerve stimulation (transcutaneous electrical nerve stimulation, scrambler therapy, vagus nerve stimulation), meditation, exercise, and cognitive behavioral therapy or combination therapies to amplify an interventions effect on the brain (e.g., tDCS during exercise, duloxetine plus exercise)

Using hydrogen peroxide-induced senescent TM3 Leydig cells as an in vitro model, we observed that FOXO4 maintains the viability of senescent Leydig cells and suppresses their apoptosis

Moreover, IGF-1 regulate mineral metabolism, participating in phosphate resorption and calcitriol production by increasing 1--hydroxylase activity

Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial