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Recent studies have revealed that glutamine (Gln), a metabolic precursor of glutamate (Glu), plays a neuroprotective role in alleviating moderate cognitive impairment through maintaining the homeostasis of the Glu-Gln cycle (Baek et al

Clinical trials have demonstrated that this combination promotes vasodilation, improves microcirculation, and ensures that oxygen-rich blood can once again reach starved tissues in the brain and muscles, thereby alleviating the heavy, leaden fatigue associated with vascular impairment

Lipopolysaccharide (LPS) represent another mechanism capable of inducting trained immunity