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Ann Allergy

Cancer Cell 31 , 127141 (2017)

The classical example of this was the recognition that an APAP overdose in the mouse causes the formation of a reactive metabolite, which first depletes glutathione (GSH) and then binds to sulfhydryl groups of proteins triggering cell death [79]

These aflatoxins then impair the airway cilia from functioning correctly, leading to reduced mucosal clearance.[ref] 4) Trichothecene mycotoxins encompass about 100 subtypes of metabolites from Fusarium species