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7b-c) while substantially higher IL-10 and TGF- levels (Fig

This is consistent with decreased BDNF-TrkB signalling caused by m HTT both in patients with HD and in HD rodent models, driving early DA dysfunction and striatal vulnerability

T cells are unable to synthesize the essential amino acid cysteine from substances such as cystine or methionine, necessitating its import from external sources for their functionality

Apoptosis can be triggered by endoplasmic reticulum (ER) stress in which glucose-regulated protein 78 (GRP78), CCAAT-enhancer-binding protein homologous protein (CHOP) and activating transcription factor 4 (ATF4) are induced by unfold protein response (UPR) to ameliorate ER stress by stimulation of apoptosis (Di Conza and Ho, 2020)