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Additionally, 20 mg/kg apigenin for 3 weeks in male mice treated with CUMS caused a decrease in the levels of provocative brain cytokines (IL-18 and IL-1), changes in oxidative stress parameters (reducing malondialdehyde (MDA) levels, and restoring the reduced glutathione (GSH) levels), and a decrease in expression of NLRP3 inflammatory activation (Li et al., 2016b)

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