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Clinically, it may be particularly helpful in patients with: Wheezing or respiratory symptoms Persistent hives or itching Abdominal cramping related to smooth muscle activation Studies in chronic idiopathic urticaria have shown that montelukast may reduce itch severity and hive frequency in some patients, particularly when used as adjunctive therapy

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Massage and muscle spasm research confirms that manual therapy reduces muscle tone, improves local circulation, and decreases pain