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6 Challenges and solutions of anti-angiogenic targeted therapy for GC Anti-angiogenic drugs target various aspects of tumor angiogenesis to block the formation of blood vessels to cut off the nutrient and supply to tumor cells, resulting in a hypoxic microenvironment (164)

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The liver breaks down alcohol into acetaldehyde, which is then oxidized into acetate by an enzyme called aldehyde dehydrogenase (ALDH)

Once inside the cell, it performs two critical functions: Antioxidant Defense: As the primary intracellular antioxidant, GSH directly neutralizes reactive oxygen species (free radicals) that damage DNA and cellular structures