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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

Crohn's Disease and Celiac Disease: Both of these inflammatory conditions can damage the terminal ileumthe very last section of the small intestine where B12 absorption happens

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