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Description

Interestingly, although MHI-148 has been reported to permeate the BBB in intracranial GBM models, near-infrared images of a healthy mouse brain 4 hours after retro-orbital injection of MHI-148 showed no significant fluorescence, reinforcing the tumor-specificity of HMCDs

Simpson, P

F.SharpeM

To address this, researchers have developed strategies such as local administration, targeting ligands on CPPs, or using activatable CPPs that penetrate only under specific biological stimuli