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It was also found that intracranial irradiation of mice also caused significant changes in p53 aggregation and apoptosis levels in the spleens (145)

The initial biochemical reaction involves the conversion of ethanol to acetaldehyde, which is primarily mediated by alcohol dehydrogenase and, to a lesser extent, by CYP2E1 and catalase [14]

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Apart from being a target for sex hormones, the brain is now recognized as a steroidogenic organ, and the degree to what neurosteroidogenesis, i.e., the synthesis on neuroactive steroids in the brain, affects its function has recently started to be unraveled