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The authors found that, on average, smoking a packet of cigarettes a day led to: 150 mutations in each lung cell every year 97 in the larynx or voice box 23 in the mouth 18 in the bladder six in the liver Joint lead author Prof Sir Mike Stratton, from the Wellcome Trust Sanger Institute, said: The more mutations there are, the higher the chance that these will occur in the key genes that we call cancer genes, which convert a normal cell into a cancer cell. The researchers said that in tissues such as the lung, which are directly exposed to smoke, they could find the mutational signature of the chemicals in tobacco smoke, of which at least 60 are carcinogens

doi:10.1177/1469540512474528