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Liu and colleagues expressed human MeCP2 32 in the macaque brain to mimic an ASD resulting from duplications of the MECP2 -containing genome segment, whereas Zhao and colleagues introduced deletions to SHANK3 33 , which are known to cause ASD

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In addition to motor dysfunction, patients often exhibit non-motor symptoms, such as autonomic dysfunctions, cognitive changes, and sleep disturbances, which can precede motor symptoms and significantly impact quality of life [79]