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The research suggests that for people with normal kidney function, B12 supplementation is generally safe

Some people may combine forms depending on goals, but total dosage, tolerance, and personal needs should be considered to avoid unnecessary supplementation

These findings contrast with studies undertaken in mice with other methaemoglobin-inducing agents (4-dimethylaminophenol and hydroxylamine), which produced higher peak methaemoglobin levels more quickly (Kruszyna et al., 1982)

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