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Psychiatry and Behavioral Science, University of California San Francisco, San Francisco, California (Krystal)

Bull Exp Biol Med 2012;153:2558

Case-based answers Case 1 Answer C is correct

In the HLA-matched setting, recurrent HLA loss and downregulation of MHC class II genes have also been identified as a mechanism of leukemic escape and relapse, likely due to loss of leukemia-associated antigens and/or mHAgs (204, 205)