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In aged rat models, oral 5-amino-1mq capsules significantly improved myocardial mitochondrial function, reduced cardiomyocyte apoptosis, decreased myocardial injury markers (such as CK-MB, cTnI), enhanced cardiac contractility, and alleviated aging-related myocardial fibrosis

PPAR activates ATGs related to lipid metabolism and stress adaptation, whereas BRD4 and FXR act as repressors under basal or nutrient-rich conditions

Survival analyses were performed using the KaplanMeier method, and the significance of differences between survival curves calculated using the log-rank test

Diazepam Co-administration of esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of diazepam