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Skin allergies and urticaria: Estrogen decline thins the skin, weakens the barrier, increases mast cell reactivity, and reduces diamine oxidase activity, predisposing midlife women to atopic dermatitis, contact dermatitis, and chronic urticaria

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Some patients notice improvements within weeks, while full results may take several months depending on the treatment plan

In MACS, they overreact, treating minor irritants like major threats and flooding your system with histamine