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This includes the need to design rigorous clinical trials to validate the effectiveness and safety of gut microbiota interventions, establish standardized methods for gut microbiota detection and analysis, and address ethical, regulatory, and patient acceptance issues

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Those sentiments have found a champion in Kennedy, who has embraced experimental therapies as part of his broader skepticism of the medical establishment

The TGR inhibitor demonstrating greatest efficacy in treating infected mice, 2 , was also studied after oral administration: 2 (200 mg/kg p.o.) gave plasma concentrations of 0.71, 0.77, and 0.40 M at 30, 60, and 120 min, respectively (Supplementary Table 19)