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Consequently, the binding of ATGS and EP300 to P62 and LC3, two crucial autophagy proteins, enhances autophagy flux

Here we report cryo-electron microscopy (cryo-EM) structures of human OCTN2 in a substrate-free inward-facing conformation, a substrate-bound occluded conformation, and an ipratropium-bound inward-facing conformation, revealing how OCTN2 binds and transports carnitine

Furthermore, oxidative stress and inflammatory mediators, including TNF-, act synergistically to disrupt mitochondrial function, compromising oocyte maturation in PCOS (63)