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22 Examination of patient records shows that many persist on long-term FAE treatment

DNA was isolated from GSH-depleted and NAC treated cells after treatment with different doses of ASA as described in the Materials and Methods

It is when we see moderate to high numbers of these oxidant changes in RBCs (very large or multiple Heinz bodies in cats, eccentrocytes with Heinz bodies in a dog, eccentrocytes or Heinz bodies in a horse) that we attribute an anemia to oxidative injury

However, reduced dietary intake due to appetite suppression and gastrointestinal side effects may indirectly increase deficiency risk, particularly if consumption of B12-rich animal products decreases significantly