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College of Veterinary Medicine, University of Sulaimani, Sulaimani, Iraq This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

cytotoxicity data showed no toxicity to keratinocytes or fibroblasts across a six-log concentration range (0.0058 to 5800 micromolar) 3

Methods: SACRED is a phase III, prospective, multi-center, double-blind clinical trial (NCT03654053) that enrolled patients with compensated cirrhosis and clinically significant portal hypertension (CSPH), stratified upon concomitant use of nonselective beta-blockers, randomized enrollees 1:1 to simvastatin 40 mg/day versus placebo for up to 24 months at 11 Veterans Affairs Medical Centers in the United States

2018 Jul;154(1):196-206