Signal 269 YonezawaH.OsakiT.HanawaT.KurataS.ZamanC.WooT
Irrespective of their poor chemical reactivity, superoxide radicals are probably capable of interacting directly with specific intracellular targets as well as generating secondary cytotoxic species such as peroxynitrite (ONOO-) (7), which is formed via rapid radical-radical coupling reactions between O2- and nitric oxide (NO) in the vascular wall
Disclosures: Hyunseok Kim: Nothing to Disclose, Ally Hatcher: Nothing to Disclose, Vikrant Rachakonda: Nothing to Disclose, Linda Azab: Nothing to Disclose, Touseef Qureshi: Nothing to Disclose, Lixia Wang: Nothing to Disclose, Ji Hye Min: Nothing to Disclose, Polly Kirsch: Nothing to Disclose, Yee Hui Yeo: Nothing to Disclose, Walid Ayoub: Intercept: Speaking and Teaching, Mirum: Grant/Research Support, GSK: Consultant, GSK: Grant/Research Support, Madrigal: Grant/Research Support, Cymabay: Consultant, Ipsen: Grant/Research Support, Zydus: Grant/Research Support, Alexander Kuo: Nothing to Disclose, Hirsh Trivedi: Nothing to Disclose, Aarshi Vipani: Nothing to Disclose, Yun Wang: Nothing to Disclose, Stephen Pandol: Nothing to Disclose, Ju Dong Yang: Nothing to Disclose, Shelly Lu: Nothing to Disclose, Debiao Li: Nothing to Disclose 1587 HEPATOCYTE-SPECIFIC DELETION OF BETAINE HOMOCYSTEINE METHYLTRANSFERASE PROMOTES AGE-DEPENDENT PROGRESSION OF LIVER DISEASE Poonam Sagar 1 Sathish Perumal 1 Ramachandran Rajamanickam 1 Natalia Osna 1 Karuna Rasineni 1 Kusum Kharbanda 2 , 1 University of Nebraska Medical Center, 2 Department of Veterans Affairs, Veterans Affairs Nebraska-Western Iowa Health Care System Background: Betaine homocysteine methyltransferase (BHMT), an enzyme involved in one-carbon metabolism, plays a critical role in maintaining liver health
3rd-party tested for purity, made in the USA
