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The Phase 2b trial (PMID: 23714218) failed to demonstrate significant weight loss compared to placebo over 12 weeks, despite adequate sample size and dosing

Vitr Cell Dev Biol - Anim (2019) 55(4):2529

These findings suggest that GPER activation regulates Ca influx by inhibiting voltagedependent calcium channel activity

DCI arises not only from large-vessel vasospasm, but also from other complex pathophysiological processes, including thrombo-inflammation, neuro-inflammation, microcirculatory dysfunction, and glycocalyx disruption