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Another insecticidal target described by As AChE, which has a similar location and function to that of G342 in Hs AChE and D375 in Dm AChE, located at the active-site entrance

PD is the second most common neuro-degenerative disease in which the accumulation of aggregated -synuclein is the main factor contributing to disease progression [42, 43]

doi: 10.1016/S1474-4422(17)30369-1 127

This association highlights the need for robust longitudinal studies and standardized oxidative stress biomarkers to clarify causality, define the timing of redox alterations, and determine the true preventive or therapeutic relevance of targeting oxidative pathways