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Antiviral antibody activities in vivo The antiviral activities of nAbs as assessed by in vitro assays may operate in vivo but it is difficult to determine the relative contributions of the different mechanisms direct neutralization, nAb-mediated effector functions against free virions or infected cells, or virus sequestration

Above all, a thorough clinical history must also account for inter-personal variability, the potential implications of initial misdiagnosis, and the diagnostic limitations of two-tier testing

doi: 10.1016/j.mehy.2020.110412 34 CastejonA

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