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One study in Canada compared the annual prevalence of feline post-vaccinal sarcomas among 11,609 feline skin mass submissions from 1992 to 2010 and revealed no decrease in disease prevalence or increase in age of affected cats in response to change in vaccination formulations (introduction of recombinant non-adjuvanted rabies (and later FeLV) vaccines) or recommended changes in feline vaccination protocols (e.g., calling for more selective use of FeLV vaccination and less frequent rabies vaccination) (Wilcock et al., 2012)