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Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

Therefore, some of these findings would corroborate that UA may be a modifiable factor in the progression of chronic kidney disease, without sufficient data to state whether the beneficial effect of allopurinol is due to the reduction of UA or to the antioxidant effect produced by inhibiting the xanthine oxidase enzyme, however, the two large randomized clinical trials do not offer positive results so there is insufficient evidence to recommend allopurinol treatment in patients with asymptomatic hyperuricemia

This reprogramming further enhances the recruitment and activation of CTLs [203]

Yang D, Wang X, Zhang L et al (2022) Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases